Chronic Medical Conditions and Perinatal Mental Health

Disability and Pregnancy

One in five individuals experience mental in pregnancy or the first 12 months after delivery. Prior history of mental illness, stress, and lack of support are known to predict perinatal mental illness. However, despite interventions targeting these risk factors, rates of perinatal mental illness are not decreasing. Data are needed on at-risk groups who could benefit from tailored supports. We used whole-population health records in Ontario to examine the risk of perinatal mental illness in birthing people with and without a pre-existing chronic condition.

Our study had several key take-aways:

  • Birthing people with chronic conditions had higher risk of mental illness in pregnancy and postpartum compared to those without chronic conditions.
  • Individuals who entered pregnancy with a chronic condition and social risk factors, such as poverty, had the highest risks of perinatal mental illness.
  • There was also variation in risk according to chronic condition severity and symptom management.

These findings show the importance of integration of obstetric and mental health care, through co-location of services and other collaborative care approaches.

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Read more about this research

  • Brown HK, Gomes T, Wilton AS, Camden A, Guttmann A, Dennis CL, Ray JG, Vigod SN. Maternal chronic physical conditions and alcohol and substance use disorders in the preconception and perinatal periods. Journal of Women’s Health 2025;34(4):504–512.
  • Aker A, Stephenson A, Wilton D, Vigod SN, Dennis CL, Guttmann A, Brown HK. Asthma severity and control and their association with perinatal mental illness. Canadian Journal of Psychiatry 2022;67(2):156-159.
  • Aker A, Vigod SN, Dennis CL, Kaster T, Brown HK. The association between asthma and perinatal mental illness: A population-based cohort study. International Journal of Epidemiology 2022;51(3):964–973.
  • McKnight A, Vigod SN, Dennis CL, Wanigaratne S, Brown HK. Association between chronic medical conditions and acute perinatal psychiatric health care encounters among migrants: a population-based cohort study. Canadian Journal of Psychiatry 2020;65(12):854-864.
  • Faulkner MR, Barker L, Vigod SN, Dennis CL, Brown HK. Collective impact of chronic medical conditions and poverty on perinatal mental illness risk. Journal of Epidemiology & Community Health 2020;74(2):158-163.
  • Brown HK, Cairncross Z, Lipscombe L, Wilton D, Dennis CL, Ray J, Guttmann A, Vigod SN. Pre-pregnancy diabetes and perinatal mental illness: A population-based latent class analysis. American Journal of Epidemiology 2020;189(6):573-582.
  • Brown HK, Wilton D, Ray JG, Dennis CL, Guttmann A, Vigod SN. Chronic physical conditions and perinatal mental illness: A population-based retrospective cohort study. PLoS Medicine 2019;16(8):e1002864.
  • Brown HK, Qazilbash A, Rahim N, Dennis CL, Vigod SN Chronic medical conditions and peripartum mental illness: a systematic review and meta-analysis. American Journal of Epidemiology 2018;187(9):2060–2068.

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People on this project

Principal Investigator: Hilary Brown; Co-Investigators: Cindy-Lee Dennis, Astrid Guttmann, Joel Ray, Simone Vigod

Partners

Provincial Council for Maternal and Child Health

Project funders

Canadian Institutes of Health Research

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Interested in getting involved? For inquiries and more information about our research, please contact us.